TBPH-1

SKU: orb3173616

Description

TBPH is a brominated flame retardant that exacerbates hepatic steatosis, inflammation, and fibrosis in non-alcoholic steatohepatitis (NASH) mouse models. It disrupts phospholipid metabolism, reducing levels of cardiolipin (CL) and phosphatidylserine (PS). TBPH impairs endoplasmic reticulum-mitochondria (ER-Mito) contact, leading to mitochondrial dysfunction. Additionally, TBPH induces lung injury through a mitochondrial-derived ds-DNA mediated inflammatory response. It is also used to investigate the role of MFN2-mediated ER-Mito contact in lipid metabolism homeostasis.

Key Properties

• CAS Number: 26040-51-7
• MW: 706.15
• Formula: C₂₄H₃₄Br₄O₄
• SMILES: O=C(OCC(CC)CCCC)C=1C(Br)=C(Br)C(Br)=C(Br)C1C(=O)OCC(CC)CCCC
• Target: LDLR,Cytochromes P450,Protease,Interleukin,HSP,PERK,Mitochondrial Metabolism,TNF

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

LDLR,Cytochromes P450,Protease,Interleukin,HSP,PERK,Mitochondrial Metabolism,TNF