TBK1-IN-2

SKU: orb3027574

Description

TBK1-IN-2 (Compound A1) is a potent inhibitor of TBK1 with an IC50 of 775 pM. It binds to TBK1 through stable hydrogen bonding and π-π stacking interactions, thereby inhibiting the phosphorylation of IRF3. TBK1-IN-2 works in synergy with TNF/IFNγ to enhance immune-mediated tumor cell death and is applicable in cancer immunotherapy research.

Research Area

Signal Transduction

Key Properties

• CAS Number: 3075572-35-6
• MW: 519.55
• Formula: C₂₆H₂₉N₇O₅
• SMILES: O=C(OCC=1C=CC=CC1)NC2CCN(C(=O)NC3=CNN=C3C4=NC=5C=C(OC)C(OC)=CC5N4)CC2
• Target: IκB/IKK

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

IκB/IKK