TBK1-IN-1

SKU: orb1744266

Description

TBK1-IN-1 is a potent and selective inhibitor of TANK-binding kinase 1 (TBK1), demonstrating an IC50 of 22.4 nM. It suppresses downstream TBK1 signaling, including the expression of cxcl10 and ifnβ, and is a valuable chemical probe for studying TBK1's role in oncology, immunology, and inflammatory disease research in cellular models.

Research Area

Signal Transduction

Key Properties

• CAS Number: 3031785-78-8
• MW: 491.63
• Purity: >99.99% (May vary between batches)
• Formula: C₂₇H₃₇N₇O₂
• SMILES: O=C(NCCCN1CCC2=CN=C(NC3=CC=CC(CN4CCN(C(C)=O)CC4)=C3)N=C21)C5CCC5
• Target: IκB/IKK
• Solubility: DMSO:80 mg/mL (162.72 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (6.71 mM)

Bioactivity

• Target IC50:
  TBK1:22.4 nM
• In Vitro:
  TBK1-IN-1 (1-100 μM; 72 h) inhibits the growth of A549 and LLC cells in a dose-dependent manner and suppresses the phosphorylation of downstream signaling effector protein S6K of TBK1.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

IkB, IkB/IKK, IKK, IκB, TBK1

Compound Identifiers

PubChem CID

171360930