Tazobactam

SKU: orb1309188

Description

Tazobactam (YTR-830H) is a penicillanic acid sulfone derivative that acts as a potent and irreversible β-lactamase inhibitor. It is widely used in research, both in vitro and in vivo, to restore the efficacy of β-lactam antibiotics against resistant bacterial strains.

Research Area

Infectious Disease & Virology

Key Properties

• CAS Number: 89786-04-9
• MW: 300.29
• Purity: >99.99% (May vary between batches)
• Formula: C₁₀H₁₂N₄O₅S
• SMILES: C([C@@]1(C)[C@H](C(O)=O)N2[C@](S1(=O)=O)(CC2=O)[H])N3C=CN=N3
• Target: Antibacterial,Antibiotic
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.66 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble);DMSO:55 mg/mL (183.16 mM)

Bioactivity

• In Vivo:
  Propylthiouracil-induced hypothyroidism reduces oxidative damage in the lung, hepatic, renal and ileal tissues probably due to hypometabolism in rats, which is associated with decreased production of reactive oxygen metabolites and enhancement of antioxidant mechanisms. Propylthiouracil-induced congenital hypothyroidism upregulates vimentin phosphorylation and depletes antioxidant defenses in immature rat testis. Propylthiouracil results in lesser concentrations of thyroxine (T4) and triiodothyronine (T3), greater concentrations of follicle stimulating hormone (FSH) and luteinizing hormone (LH) peptides, and increase in steroidogenic gene expression after 12 hours and 48 hours in zebrafish. Propylthiouracil-induced hypothyroidism is associated with increased tolerance of the isolated rat heart toischaemia-reperfusion. Propylthiouracil (PTU) dramatically reduces thyroid hormones on PND21 and produced deficits in body weight that persisted to adulthood in developing rats. Propylthiouracil inhibits both the synthesis of thyroid hormones in the thyroid gland and the conversion of T4 to its active form, T3. Propylthiouracil treatment significantly increases circulating TSH at both P3 and P7. Propylthiouracil exposure of adult rats, at a dose inducing modest reductions in circulating T4 concentrations and no significant effect on brain BDNF, significantly alteres the thyroid hormones and hippocampal BDNF levels in the offspring at 3 and 7 d after birth.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Bacterial, Antibiotic, CL 298741, CL298741, CL-298741, YTR-830H, Tazobactam, Tazobactam acid, Tazobactamum, β-Lactamase

Compound Identifiers

PubChem CID

123630