Tazarotene

SKU: orb1300547

Description

Tazarotene is a synthetic topical retinoid that upregulates the tumor suppressor TIG3, normalizing aberrant keratinocyte differentiation and proliferation in psoriasis. It is widely used in dermatological research, with applications in both in vitro cell culture studies and in vivo models of hyperproliferative skin disorders.

Research Area

Cell Biology, Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 118292-40-3
• MW: 351.46
• Purity: 99.67% (May vary between batches)
• Formula: C₂₁H₂₁NO₂S
• SMILES: CC1(C)C=2C(=CC=C(C#CC3=CC=C(C(OCC)=O)C=N3)C2)SCC1
• Target: Autophagy,Retinoid Receptor
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.69 mM);DMSO:16.67 mg/mL (47.43 mM);Ethanol:17.6 mg/mL (50.08 mM)

Bioactivity

• In Vivo:
  Tazarotene treatment reduces the number and size of microscopic basal cell carcinomas (BCCs) in UV-treated Ptch1+/ mice. Tazarotene treatment reduces the number and size of microscopic basal cell carcinomas (BCCs) in ionizing radiation-treated Ptch1+/ mice.
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• In Vitro:
  Tazarotene causes ERK activation, RB tumor suppressor protein hypophosphorylation, G0 arrest, and myeloid differentiation in HL-60 human myeloblastic leukemia cells. Tazarotene could propel either early or late portions of the period leading to differentiation and G0 arrest and is interchangeable with an RARalpha-selective ligand. Tazarotene therapy regulates gene transcription via interaction with specific nuclear retinoic acid receptors (RARs), thereby modulating the three key pathogenic factors in psoriasis. Tazarotene inhibits the proliferation of fibroblasts and synthesis of DNA and collagen. Tazarotene down-regulates markers of keratinocyte differentiation, keratinocyte proliferation, and inflammation. Tazarotene also up-regulates three novel genes TIG-1 (tazarotene-induced gene-1), TIG-2, and TIG-3, which may mediate an antiproliferative effect. Tazarotene causes growth suppression in retinoid-responsive breast cancer cell lines by up-regulating TIG3.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

AGN 190168, AGN190168, AGN-190168, Autophagy, inhibit, Inhibitor, RAR, RAR/RXR, Tazarotene, Tazorac, Retinoic acid receptors, Retinoid Receptor, Retinoid X receptors, RetinoidReceptor, Zorac

Compound Identifiers

PubChem CID

5381