Taurolidine

SKU: orb1299733

Description

Taurolidine is a synthetic derivative of taurine with broad-spectrum antimicrobial and anti-tumor properties. It is widely used in research for studying infection control, biofilm disruption, and its cytotoxic effects against various cancer cell lines in both in vitro and in vivo models.

Research Area

Cell Biology, Infectious Disease & Virology, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 19388-87-5
• MW: 284.36
• Purity: 99.81% (May vary between batches)
• Formula: C₇H₁₆N₄O₄S₂
• SMILES: O=S1(=O)CCN(CN2CCS(=O)(=O)NC2)CN1
• Target: Antibiotic,Antibacterial,Apoptosis,Autophagy
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (7.03 mM);DMSO:50 mg/mL (175.83 mM)

Bioactivity

• In Vivo:
  In vivo, local Taurolidine administration resulted in significant decreases in tumor burden (3+/-1 nodules in Group B animals vs. 649+/-101 nodules in Group A animals).
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• In Vitro:
  Incubation of the tumor cells with Taurolidine resulted in a 4-fold decrease in proliferation rates (25+/-4% vs. 100+/-28% for controls) and a 4-fold increase in cell necrosis as demonstrated by the increase in LDH release (403+/-28% vs. 100+/-26% for controls), at a Taurolidine concentration of 25 microg/ml. A dose-dependent decrease in cell viability was also observed.
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• Cell Research:
  In the in vitro experiments, DHD/K12/TRb cells were incubated with 5, 10, 15, 25, microg/ml of Taurolidine. Cells incubated in culture medium alone were used as controls. Cell proliferation, cell viability, cell death, and cell apoptosis were measured using commercially available techniques.
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• Animal Research:
  In the in vivo experiment, BD IX rats were randomized into two groups (n = 10/group). Group A (control) underwent laparotomy and instillation of DHD/K12/TRb tumor cells intraperitoneally followed by phosphate buffered saline (PBS). Group B received Taurolidine (100 mg/kg) instead of PBS. Animals were killed after 24 days and tumor burden assessed by counting the number of tumor nodules in the peritoneal cavity.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, infections, inhibit, catheter-related, catheters, Bacterial, Apoptosis, antiseptic, antimicrobial, Antibiotic, central, CVC, CRBSI, Taurolidine, venous

Compound Identifiers

PubChem CID

29566