Taurochenodeoxycholic Acid

SKU: orb1304752

Description

Taurochenodeoxycholic Acid

Research Area

Cell Biology, Metabolism Research, Protein Biochemistry

Key Properties

• CAS Number: 516-35-8
• MW: 499.7
• Purity: 99.53%
• Formula: C₂₆H₄₅NO₆S
• SMILES: C[C@@]12[C@]([C@]3([C@@]([C@]4(C)[C@](C[C@H]3O)(C[C@H](O)CC4)[H])(CC1)[H])[H])(CC[C@@]2([C@@H](CCC(NCCS(=O)(=O)O)=O)C)[H])[H]
• Target: Apoptosis,Endogenous Metabolite,Caspase,TNF
• Solubility: DMSO:50 mg/mL (100.06 mM);H2O:100 mg/mL (200.12 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4 mM)

Bioactivity

• In Vivo:
  Taurochenodeoxycholic acid significantly normalize the clinical inflammatory parameters, prevented indomethacin-induced increases in the biliary contents of secondary bile acids and hydrophobicity index, and tended to attenuat the intestinal inflammation. Taurochenodeoxycholic acid significantly suppresses paw swelling and polyarthritis index, increase the loss body weight and index of thymus and spleen, and amends radiologic Changes in AA rats the overproduction and mRNA expression of TNF-α, IL-1β and IL-6 are remarkably suppressed in serum and synovium tissue of All TCDCA-treated rats.Taurochenodeoxycholic acid in dosages of 0.05 and 0.1g/kg can decreas the pulmonary coefficient in the model mice, taurochenodeoxycholic acid in dosages of 0.05 and 0.1g/kg reduc the pathological damages on their lungs; it can decreas the expression levels of TNF-α and TIMP-2 in pulmonary tissues in the pulmonary fibrosis mice the expression level of MMP-9 increases, while it has no significant effects on MMP2.
• In Vitro:
  Studies have suggested that taurochenodeoxycholic acid as a signaling molecule shows obvious anti-inflammatory and immune regulation properties. Taurochenodeoxycholic acid dramatically improve the apoptosis rate of NR8383 cells in a concentration dependent manner. in the meantime, PKC mRNA levels and activities are significantly augmented by taurochenodeoxycholic acid treatments. In addition, JNK, caspase-3 and caspase-8 mRNA expression levels and activities are increased by taurochenodeoxycholic acid.

Storage & Handling

• Storage: keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

acid, 12-Deoxycholyltaurine, bile, Apoptosis, anti-inflammatory, Chenyltaurine, Chenodeoxycholyltaurine, Caspase, caspase-3, caspase-8, inhibit, JNK, mRNA, immune, NR8383, Inhibitor, EndogenousMetabolite, Endogenous Metabolite, Taurochenodeoxycholate, Taurochenodeoxycholic Acid, TCDCA, regulation, TNF-α, TIMP-2, PKC

Compound Identifiers

PubChem CID

387316