Tau Protein Phosphorylation-IN-1

SKU: orb3173622

Description

Tau ProteinPhosphorylation-IN-1 is a tau protein phosphorylation inhibitor that effectively protects PC12 cells from Aβ25-35-induced cytotoxicity (EC50 = 1.93 μM) and is capable of crossing the blood-brain barrier. It reverses tau protein hyperphosphorylation both in vitro and in vivo, significantly suppresses the expression of immune-related cytotoxic factors, blocks the MAPK and NF-κB signaling pathways, and reduces the levels of RAGE and apoptosis factor Bax/Bcl-2. In Alzheimer's disease mouse models, Tau ProteinPhosphorylation-IN-1 alleviates neuronal damage and improves learning and memory capabilities. It is applicable for Alzheimer's disease research.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 3075165-36-2
• MW: 628.9
• Formula: C₃₉H₅₆N₄O₃
• SMILES: C(OCCN1C(=NN=N1)C2=CC=CC=C2)(=O)[C@]34[C@](C=5[C@@](C)(CC3)[C@@]6(C)[C@](CC5)([C@]7(C)[C@@](CC6)(C(C)(C)[C@@H](O)CC7)[H])[H])(CC(C)(C)CC4)[H]
• Target: Apoptosis,JNK,Microtubule Associated,ERK,p38 MAPK,Bcl-2 Family,NF-κB

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Apoptosis,JNK,Microtubule Associated,ERK,p38 MAPK,Bcl-2 Family,NF-κB