TAT-PiET-PROTAC

SKU: orb3142351

Description

TAT-PiET-PROTAC is a TAT-PiET modified by a proteolysis targeting chimera (PROTAC). TAT-PiET is a cell-penetrating peptide that targets the extra-terminal (ET) domain of BRD4. TAT-PiET-PROTAC disrupts the interaction between BRD4 and the oncogene JMJD6 in breast cancer, effectively inhibiting the growth of these cancer cells. Additionally, it combats endocrine resistance in ERα-positive breast cancer cells, making it a promising breast cancer inhibitor. TAT-PiET-PROTAC is also utilized in the synthesis/research of radiolabeled conjugate drugs (RDC).

Research Area

Epigenetics & Chromatin, Signal Transduction

Key Properties

• Target: Epigenetic Reader Domain
• Formula: C₁₄₅H₂₃₉N₅₃O₃₅S

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Epigenetic Reader Domain