Tat-CIRP

• Catalog Number: orb1140645
• Category: Proteins
• Description: MD2 - CIRP interaction blocker; Cell penetrating peptides.
• Modifications: None
• Structure: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Arg-Gly-Phe-Ser-Arg-Gly-Gly-Gly-Asp-Arg-Gly-Tyr-Gly-Gly-OH
• Target Areas: Protein-protein interactions, Toll like receptors
• Form/Appearance: Freeze dried solid
• Purity: > 95% by hplc
• MW: 2997.34 Da
• Formula: C₁₂₃H₂₀₆N₅₆O₃₃
• Solubility (25°C): Soluble in water
• Protein Sequence: H-Tyr-Gly-Arg-Lys-Lys-Arg-Arg-Gln-Arg-Arg-Arg-Gly-Arg-Gly-Phe-Ser-Arg-Gly-Gly-Gly-Asp-Arg-Gly-Tyr-Gly-Gly-OH
• Storage: Store dry, frozen and in the dark
• Alternative names: Tat-cold inducible RNA binding protein
• Background: Tat-CIRP is a peptide derived from the high affinity binding region of cold-inducible RNA binding protein (CIRP) which competitively binds to myeloiddifferentiation factor 2 (MD2) and blocks the MD2-CIRP interaction. MD2 is an essential accessory protein forToll like receptor 4 (TLR4) activation and blocking the function of MD2 and TLR4 with Tat-CIRP is neuroprotective, reducing apoptosis andnecroptosis in vitro. In vivo, Tat-CIRP is neuroprotective against ischemic and hemorrhagic stroke in mice and reduces brain infarct volume and preserves neurological function in rhesus monkeys 30 days after ischemic stroke.
• Note: For research use only
• Expiration Date: 12 months from date of receipt.