Tat-beclin 1 TFA

• Catalog Number: orb1981403
• Category: Small Molecules
• Description: Tat-beclin 1 TFA, a peptide derived from a segment of the autophagy protein beclin 1, effectively induces autophagy and interacts with the autophagy negative regulator GAPR-1 (GLIPR2). It reduces the accumulation of polyglutamine expansion protein aggregates and limits the in vitro replication of various pathogens, including HIV-1. Additionally, Tat-beclin 1 TFA has been shown to decrease mortality rates in mice infected with chikungunya (CHIKV) or West Nile virus (WNV) [1].
• Purity: 98.00%
• MW: 3855.12
• Formula: C₁₆₆H₂₅₂F₃N₅₇O₄₇
• Biological Activity: Tat-beclin 1 TFA, a peptide originating from a segment of the autophagy protein beclin 1, effectively initiates autophagy and engages with the autophagy negative regulator, GAPR-1 (GLIPR2). It notably reduces the buildup of polyglutamine expansion protein aggregates and curtails the in vitro replication of various pathogens, including HIV-1. Moreover, Tat-beclin 1 TFA has demonstrated a reduction in mortality rates in mice infected with either chikungunya (CHIKV) or West Nile virus (WNV) [1].
• Storage: -20°C
• Note: For research use only
• Expiration Date: 12 months from date of receipt.