TASP0415914

SKU: orb1299421

Description

TASP0415914 is a potent and orally bioavailable small molecule inhibitor targeting phosphoinositide 3-kinase gamma (PI3Kγ). It is a valuable research tool for studying the role of PI3Kγ in inflammation and immuno-oncology, with utility in both in vitro cellular assays and in vivo disease models.

Research Area

Signal Transduction

Key Properties

• CAS Number: 1292300-75-4
• MW: 323.37
• Purity: >99.99% (May vary between batches)
• Formula: C₁₃H₁₇N₅O₃S
• SMILES: CC(=O)Nc1nc(C)c(s1)-c1nc(no1)N1CCCC(O)C1
• Target: Akt,PI3K
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.18 mM);DMSO:11 mg/mL (34.02 mM)

Bioactivity

• Target IC50:
  Akt:294 nM (IC50)|PI3Kγ:29 nM (IC50)
• In Vivo:
  TASP0415914 demonstrated good potency in a cell-based assay and, furthermore, exhibited in vivo efficacy in a collagen induced arthritis (CIA) model in mice after oral administration.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, inhibit, inflammatory, oral, metabolic, autoimmune, Akt, Protein kinase B, TASP0415914, TASP-0415914, TASP 0415914, stability, Phosphoinositide 3-kinase, PKB, PI3K, PI3Kγ

Compound Identifiers

PubChem CID

72737552