TASIN-1

SKU: orb1305413

Description

TASIN-1 Hydrochloride is a selective small molecule that induces apoptosis in colorectal cancer cells expressing truncated APC. It acts by depleting cellular cholesterol, triggering ER stress and activating the ROS/JNK signaling pathway. This compound is a valuable research tool for studying APC-mutant cancer biology in both in vitro and in vivo models.

Research Area

Cell Biology

Key Properties

• CAS Number: 1678515-13-3
• MW: 389.0
• Purity: >98%
• Formula: C₁₈H₂₈N₂O₃S·HCl
• SMILES: CC1CCN(CC1)C2CCN(CC2)S(=O)(C3=CC=C(C=C3)OC)=O.[H]Cl
• Target: JNK,APC/C,ROS,Caspase,Apoptosis
• Solubility: Soluble in DMSO (up to 20 mg/ml)

Bioactivity

• Target IC50:
  APC:70 nM(DLD1 cells)
• In Vivo:
  In nude mice with established DLD1 and HT29 tumors, intraperitoneal injection of TASIN-1 twice daily for 18 days reduced the size of tumor xenografts and tumor growth rates. TASIN-1 resulted in the appearance of apoptotic cells with fragmented nuclei and induced an increase in cleaved caspase 3 and cleaved PARP1. However, TASIN-1 did not inhibit tumor growth in HCT116 xenografts. In a genetically engineered CRC mouse model, TASIN-1 significantly reduced tumor formation in the colons of CPC .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TASIN 1 HCl, TASIN 1 Hydrochloride, TASIN1 HCl, TASIN-1 HCl, TASIN1 Hydrochloride, TASIN-1 Hydrochloride, APC

Compound Identifiers

PubChem CID

132470901