Tasimelteon

SKU: orb1304147

Description

Tasimelteon (BMS-214778) is a selective melatonin receptor agonist used to treat Non-24-Hour Sleep-Wake Disorder. It is widely applied in circadian rhythm research, with studies demonstrating its in vivo efficacy in entraining sleep-wake cycles in blind individuals and its in vitro binding affinity for MT1 and MT2 receptors.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 609799-22-6
• MW: 245.32
• Purity: 98.08% (May vary between batches)
• Formula: C₁₅H₁₉NO₂
• SMILES: CCC(=O)NC[C@@H]1C[C@H]1c1cccc2OCCc12
• Target: Melatonin Receptor,MT Receptor
• Solubility: DMSO:50 mg/mL (203.82 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.15 mM)

Bioactivity

• Target IC50:
  MT2 receptor:9.8(pKi)|MT1 receptor:9.45(pKi)

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Melatonin Receptor, MelatoninReceptor, Inhibitor, orally, MT1, MT1 receptor, MT Receptor, MT2, MT2 receptor, MTReceptor, inhibit, Non-24, DMRA, circadian, BMS 214778, BMS214778, BMS-214778, Tasimelteon, regulator, VEC162, VEC-162, VEC 162

Compound Identifiers

PubChem CID

10220503