TAS6417

SKU: orb1218670

Description

TAS6417 is an EGFR inhibitor and is an efficacious drug candidate for patients with NSCLC (IC50: ranging from 1.1-8.0 nM).

Key Properties

• CAS Number: 1661854-97-2
• MW: 396.44
• Purity: >98% (HPLC)
• Formula: C₂₃H₂₀N₆O
• SMILES: CC1=C[C@@H](CN2C1=C(C3=C(N=CN=C32)N)C4=CC5=CC=CC=C5N=C4)NC(=O)C=C
• Target: Apoptosis
• Solubility: DMSO:125 mg/mL (315.31 mM)

Bioactivity

• In Vivo:
  Animal model: Mice implanted with NCI-H1975 EGFR D770_N771insSVD xenografts. Dosage: 50 and 100 mg/kg. Administration: Orally once daily for 14 days. Result: Showed marked tumor growth inhibition with treatment/control (T/C) ratios of 51% and 19%, respectively.
• In Vitro:
  Apoptosis Analysis Cell line: PC-9, H1975, BID007, BID019, BEAS-2B cells. Concentration: 0-10 μM. Incubation time: 24-48 h. Result: Led to apoptosis via inhibition of mutant EGFR.

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Apoptosis