TAS4464 hydrochloride

SKU: orb1309030

Description

TAS4464 hydrochloride is a potent and selective NEDD8-activating enzyme (NAE) inhibitor with an IC50 of 0.955 nM. It is a valuable research tool for investigating the neddylation pathway in oncology research, demonstrating activity in both cellular and in vivo models of cancer.

Research Area

Metabolism Research, Protein Biochemistry

Key Properties

• CAS Number: 1848959-11-4
• MW: 542.97
• Purity: 98.96% (May vary between batches)
• Formula: C₂₁H₂₄ClFN₆O₆S
• SMILES: Cl.CCOc1cccc(F)c1C#Cc1cn([C@@H]2O[C@H](CNS(N)(=O)=O)[C@@H](O)[C@H]2O)c2ncnc(N)c12
• Target: NEDD8,E1/E2/E3 Enzyme
• Solubility: 30% PEG300+70% Saline:5 mg/mL (9.21 mM);H2O:4 mg/mL (7.37 mM);DMSO:80 mg/mL (147.34 mM)

Bioactivity

• Target IC50:
  NAE:0.955 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, NEDD8-activating Enzyme, NEDD8, NAE, inhibit, E1Enzyme, E1 Enzyme, E2 Enzyme, E2Enzyme, E3 Enzyme, E3Enzyme, TAS4464, TAS-4464, TAS4464 Hydrochloride, TAS4464 hydrochloride, TAS-4464 Hydrochloride, TAS-4464 hydrochloride, TAS 4464, TAS 4464 Hydrochloride

Compound Identifiers

PubChem CID

124121823