TAS2940 free base

SKU: orb2815183

Description

TAS2940 is an irreversible pan-ERBB inhibitor designed for enhanced brain penetration, showing efficacy in intracranial xenograft models of HER2/EGFR-altered cancers. It is currently in Phase I trials for solid tumors, including lung cancer brain metastases and glioblastoma, supporting preclinical in vivo and in vitro oncology research.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 2451398-65-3
• MW: 482.58
• Formula: C₂₈H₃₀N₆O₂
• SMILES: C(#CC1CC1)C=2N(C=3C(C2C(N[C@H](C)C4=CC=CC=C4)=O)=C(N)N=CN3)[C@H]5CN(C(C=C)=O)[C@@H](C)C5
• Target: EGFR

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

154642628