TAS-121

SKU: orb2663940

Description

TAS-121 is a potent, covalent third-generation EGFR-TKI that selectively targets mutant EGFR forms, including T790M resistance mutations, and inhibits HER2/4. It demonstrates robust antitumor efficacy in cellular assays and in vivo xenograft models, such as NCI-H1975, by blocking EGFR phosphorylation and downstream signaling.

Key Properties

• CAS Number: 1451370-01-6
• MW: 384.43
• Formula: C₂₂H₂₀N₆O
• SMILES: NC1=C2C(=C3N(C2=NC=N1)C[C@@H](NC(C=C)=O)CC3)C4=CC5=C(N=C4)C=CC=C5

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

71682991