Tarlox-TKI

SKU: orb1709334

Description

Tarlox-TKI is the active kinase inhibitor component of Tarloxotinib, functioning as a pan-ErbB inhibitor. It demonstrates antitumor activity by inhibiting NRG1 and suppressing HER2 mutants, making it a valuable tool for in vitro and in vivo cancer research targeting ErbB-driven pathways.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 2135696-72-7
• MW: 461.74
• Purity: 97.03% (May vary between batches)
• Formula: C₁₉H₁₈BrClN₆O
• SMILES: CN(C)C\C=C\C(=O)Nc1cc2c(Nc3ccc(Cl)c(Br)c3)ncnc2cn1
• Target: EGFR
• Solubility: DMSO:80 mg/mL (173.26 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:3.3 mg/mL (7.15 mM)

Bioactivity

• In Vitro:
  Tarlox-TKI is a kinase inhibitor that targets EGFR, becoming a therapeutic target for many cancer types.

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

ErbB, Kinase, Kinase inhibitor-1, Tarlox TKI, TarloxTKI, Tarlox-TKI

Compound Identifiers

PubChem CID

51037658