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Tariquidar

SKU: orb1225719

Description

A potent, specific P-gp inhibitor with Kd of 5.1 nM; potentiates the cytotoxicity of several drugs including doxorubicin, paclitaxel, etoposide, and vincristine in a panel of human MDR cell lines at 25-80 nM; exhibits potent i.v. and p.o. activity without apparently enhancing the plasma pharmacokinetics of paclitaxel or the toxicity of coadministered drugs.Breast Cancer Phase 2 Discontinued.

Images & Validation

Key Properties

CAS Number206873-63-4
MW646.7315
Purity>98% (HPLC)
FormulaC38H38N4O6
SMILESCOC1=CC2=C(CN(CCC3=CC=C(NC(=O)C4=C(NC(=O)C5=CC6=CC=CC=C6N=C5)C=C(OC)C(OC)=C4)C=C3)CC2)C=C1OC |c:17,26,28,31,40,43,49,t:2,4,10,12,22,24,34|
TargetP-glycoprotein
SolubilityDMSO: ≥ 100 mg/mL

Storage & Handling

StorageStorage temperature: -20°C. Stability: ≥ 2 years
Expiration Date12 months from date of receipt.
DisclaimerFor research use only

Alternative Names

XR 9576 | XR-9576 | XR9576

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Tariquidar (orb1225719)

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% DMSO +
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% Tween 80 +
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200 mg
500 mg
5 mg
$ 90.00
10 mg
$ 130.00
25 mg
$ 200.00
50 mg
$ 340.00
100 mg
$ 540.00