Tarenflurbil

SKU: orb1689861

Description

Tarenflurbil

Research Area

Cell Biology, Metabolism Research

Key Properties

• CAS Number: 51543-40-9
• MW: 244.26
• Purity: 99.90%
• Formula: C₁₅H₁₃FO₂
• SMILES: C[C@@H](C(O)=O)c1ccc(c(F)c1)-c1ccccc1
• Target: Retinoid Receptor,Autophagy
• Solubility: DMSO:50 mg/mL (204.7 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (8.19 mM)

Bioactivity

• Target IC50:
  RXRα:75 μM
• In Vivo:
  Oral R-flurbiprofen prevented and attenuated primary progressive EAE in C57BL6/J mice and relapsing-remitting EAE in SJL mice, even if the treatment was initiated on or after the first flare of the disease. R-flurbiprofen reduced immune cell infiltration and microglia activation and inflammation in the spinal cord, brain and optic nerve and attenuated myelin destruction and EAE-evoked hyperalgesia. R-flurbiprofen treatment increased CD4(+)CD25(+)FoxP3(+) regulatory T cells, CTLA4(+) inhibitory T cells and interleukin-10, whereas the EAE-evoked upregulation of pro-inflammatory genes in the spinal cord was strongly reduced. The effects were associated with an increase of plasma and cortical endocannabinoids but decreased spinal prostaglandins, the latter likely due to R to S inversion.
• Animal Research:
  Bone marrow transplantation (BMX), recipient C57BL6/J mice received a 9.5 Gy cobalt 60 gamma irradiation and subsequently an intravenous injection through the tail vein of 6 × 10^6 bone marrow cells, which were harvested from tibia and femur of β-actin-EGFP donor mice. Immunization was done with MOG35-55/CFA emulsion plus PTX 3 weeks after BMX and treatment with R-flurbiprofen or vehicle started 3 days after immunization.

Storage & Handling

• Storage: store at low temperature | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

(R)-Flurbiprofen, Autophagy, inhibit, MPC 7869, MPC7869, MPC-7869, Inhibitor, Flurbiprofen, RAR/RXR, RXRα, Tarenflurbil, RetinoidReceptor, Retinoid X receptors, R-flurbiprofen, Retinoid Receptor, Retinoic acid receptors

Compound Identifiers

PubChem CID

92337