TAPI1 acetate

SKU: orb2944220

Description

TAPI1 acetate is the salt form of TAPI1, a potent inhibitor of TACE/ADAM17 and MMPs that blocks the shedding of TNF-α and its receptors. It is widely used in vitro and in vivo to study inflammatory signaling and has been shown to enhance cisplatin-induced apoptosis in esophageal squamous cell carcinoma models by suppressing NF-κB activity.

Research Area

Immunology & Inflammation, Protein Biochemistry

Key Properties

• MW: 559.65
• Purity: 99.94% (May vary between batches)
• Formula: C₂₈H₄₁N₅O₇
• SMILES: CC(C[C@@H](C(N[C@H](C(N[C@H](C(NCCN)=O)C)=O)Cc(cc1)cc2c1cccc2)=O)CC(NO)=O)C.CC(O)=O
• Target: ADAM,MMP

Bioactivity

• In Vitro:
  Methods: HK2 cells were pretreated with TAPI1 acetate (1 μM for 30 minutes) and then treated with 10 μg/ml LPS for 8 hours. Cell viability was measured by CCK8. Results: TAPI1 acetate increased the cell viability of HK-2 cells treated with LPS.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

TAPI 1 acetate, TAPI1 acetate（163847-77-6 Free base）

Compound Identifiers

PubChem CID

175667358