TAO Kinase inhibitor 1

SKU: orb1307702

Description

TAO Kinase inhibitor 1 is a potent, selective ATP-competitive inhibitor of TAOK1 and TAOK2 (IC50 11-15 nM). It functions by delaying mitotic progression and inducing mitotic cell death, making it a valuable tool for studying cell cycle regulation and apoptosis in cancer research models, both in vitro and in vivo.

Research Area

Pharmacology & Drug Discovery, Signal Transduction

Key Properties

• CAS Number: 850467-66-2
• MW: 384.47
• Purity: 99.45% (May vary between batches)
• Formula: C₂₅H₂₄N₂O₂
• SMILES: N(C(CNC(=O)C1=CC=C(C=C1)C2=CC=CC=C2)=O)C3C=4C(CCC3)=CC=CC4
• Target: MAPK
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (5.2 mM);DMSO:55 mg/mL (143.05 mM)

Bioactivity

• Target IC50:
  TAOK1:11 nM|TAOK2:15 nM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CP43, CP-43, CP 43, MAP3K, MAP kinase kinase kinase, MEKK, MAPKKK, Inhibitor, inhibit, TAO Kinase inhibitor 1, TAO Kinase inhibitor1, TAO Kinase inhibitor-1, TAOK1, TAOK2

Compound Identifiers

PubChem CID

46673962