Tankyrase-IN-2

SKU: orb1708417

Description

Tankyrase-IN-2 is a potent, selective, and orally bioavailable small molecule inhibitor, demonstrating high affinity for TNKS1 (IC50=10 nM) and TNKS2 (IC50=7 nM) with significantly weaker activity against PARP1. It is a valuable chemical probe for studying Wnt/β-catenin signaling in cancer research and has been utilized in both cellular and animal models of disease.

Research Area

Epigenetics & Chromatin, Molecular Biology, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 1588870-36-3
• MW: 316.3
• Formula: C₁₇H₁₄F₂N₂O₂
• SMILES: CC(C)(O)c1ccc(cc1)-c1nc2c(F)cc(F)cc2c(=O)[nH]1
• Target: Wnt/beta-catenin,PARP

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

136236981