Tamoxifen-PEG-Clozapine

SKU: orb2945369

Description

Tamoxifen-PEG-Clozapine is a PROTAC molecule that induces targeted degradation of estrogen receptor α (ERα) by recruiting the E3 ligase component N-recognin 5. This bifunctional degrader is a valuable chemical tool for investigating ERα-dependent cancers in both cellular and animal model studies.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• MW: 943.567
• Formula: C₅₄H₆₃ClN₆O₇
• SMILES: CC/C(=C(/C1=CC=C(C=C1)O)\C2=CC=C(C=C2)OCCN(C)C(=O)CCC(=O)NCCOCCOCCOCCN3CCN(CC3)C4=NC5=C(C=CC(=C5)Cl)NC6=CC=CC=C64)/C7=CC=CC=C7
• Target: Estrogen Receptor/ERR,PROTACs

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

172676875