Tamolarizine free base

SKU: orb1695109

Description

Tamolarizine is a novel calcium channel antagonist. It is used in research to investigate calcium-mediated processes, with applications in cardiovascular and neurological studies conducted both in vitro and in vivo.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 93035-32-6
• MW: 432.55
• Purity: 98.17% (May vary between batches)
• Formula: C₂₇H₃₂N₂O₃
• SMILES: C(N1CCN(CC(O)C2=CC(OC)=C(OC)C=C2)CC1)(C3=CC=CC=C3)C4=CC=CC=C4
• Target: Calcium Channel

Bioactivity

• In Vivo:
  Tamolarizine (40 mg/kg; rats; immediately after 15-min brain ischemia) showed slight impairment of place learning during the course of this test, they later reached almost the same performance level as the sham-operated group. Selective neuronal loss in the CA1 subfield was much less in the ischemia+tamolarizine group than in the ischemia+saline group. These results indicate that tamolarizine treatment protects the hippocampus from ischemic brain damage and ameliorates place learning impairment.
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• In Vitro:
  Tamolarizine (0.1-10 microM) synergistically potentiated the cytotoxicity of doxorubicin for doxorubicin-resistant K562 cells (K562/DXR), but had hardly any synergistic effects in the parental cell line (K562) at the same concentration. Moreover, tamolarizine inhibits the P-glycoprotein pump-efflux activity in a dose-related manner and reduces the expression of the immunoreactive P-glycoprotein in K562/DXR cells as evaluated by cytofluorimetric assay.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Tamolarizine, Tamolarizine free base, Calcium Channel, CalciumChannel, NC 1100, NC1100, NC-1100

Compound Identifiers

PubChem CID

146396