Tallimustine HCl

SKU: orb1819143

Description

Tallimustine HCl is an AT-specific alkylating antitumor agent derived from distamycin that acts as a DNA inhibitor. It has been utilized in research, including in vivo studies employing severe combined immunodeficiency (SCID) mouse models of adult myelogenous leukemia, to investigate potential therapeutic strategies.

Research Area

Molecular Biology

Key Properties

• CAS Number: 118438-45-2
• MW: 734.08
• Purity: 99.62% (May vary between batches)
• Formula: C₃₂H₃₉Cl₃N₁₀O₄
• SMILES: Cl.O=C(NC=1C=C(C(=O)NC=2C=C(C(=O)NC=3C=C(C(=O)NCCC(=N)N)N(C3)C)N(C2)C)N(C1)C)C4=CC=C(C=C4)N(CCCl)CCCl
• Target: DNA,Others
• Solubility: DMSO:45 mg/mL (61.3 mM)

Bioactivity

• Target IC50:
  CEM cells:3.5 nM
• In Vivo:
  Tallimustine HCl (3 mg/kg; i.p.; ) prolonged survival and shows antileukemic activity in L1210 tumor-bearing mice and.
• In Vitro:
  Tallimustine HCl (0.1-10 μM; 4 h) causes harm to isolated SV40 DNA. Additionally, Tallimustine HCl exhibits cytotoxicity in CEM cells after 72 hours, displaying an IC50 of 3.5 nM. Tallimustine HCl (25 and 100 nM, 6 days) induces erythroid differentiation of K562 cells. Tallimustine HCl (100 nM, 6 days) increases accumulation of γ-globin mRNA in K562 cells. Tallimustine HCl (0.5 μg/mL, 1 h) arrests SW626 cells in G2/M phase.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DNA, Tallimustine HCl, Tallimustine HCl(115308-98-0 Free base)

Compound Identifiers

PubChem CID

6918104