Talipexole dihydrochloride

SKU: orb1308589

Description

Talipexole dihydrochloride (Domnin) is a multi-target agent acting as a dopamine D2 and α2-adrenoceptor agonist, and a 5-HT3 receptor antagonist, with demonstrated anti-Parkinsonian effects. It is utilized in neuroscience research for studying receptor pharmacology and dopaminergic pathways in both in vitro binding assays and in vivo animal models.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 36085-73-1
• MW: 282.23
• Purity: 99.89% (May vary between batches)
• Formula: C₁₀H₁₇Cl₂N₃S
• SMILES: Cl.Cl.Nc1nc2CCN(CC=C)CCc2s1
• Target: 5-HT Receptor,Dopamine Receptor,Adrenergic Receptor
• Solubility: DMSO:10 mg/mL (35.43 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:1 mg/mL (3.54 mM)

Bioactivity

• Target IC50:
  5-HT3 receptor:0.22 μM(Ki,rat intestinal membrane)|5-HT3 receptor:0.35 μM(Ki,rat cortical membrane)|α2-adrenoceptor (rat):25 nM
• In Vivo:
  Intracisternal injection of 10 μg/kg Talipexole dihydrochloride promotes vagal-mediated reflex bradycardia induced by injection of angiotensin in β-adrenoceptor-blocked dogs. Intravenous administration of Talipexole dihydrochloride at 30 mcg/kg initially caused an increase in blood pressure in cats. Then there is the long-term drop in blood pressure and heart rate.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

D2, Domnin, DopamineReceptor, Dopamine Receptor, Beta Receptor, 5-HT Receptor, 5-HT3, AdrenergicReceptor, Adrenergic receptor α-2, rat, Adrenergic Receptor, 5HT Receptor, 5HTReceptor, 5-hydroxytryptamine Receptor, B-HT 920, B-HT 920 Dihydrochloride, B-HT 920 dihydrochloride, B-HT920, B-HT-920, B-HT920 Dihydrochloride, B-HT-920 Dihydrochloride, inhibit, Inhibitor, α2-adrenergic receptor, Talipexole, Talipexole Dihydrochloride, Talipexole dihydrochloride, Serotonin Receptor

Compound Identifiers

PubChem CID

104870