Takeda-6d

SKU: orb1305926

Description

Takeda-6d is a potent DFG-out inhibitor targeting RAF and VEGFR2 kinases, exhibiting IC50 values of 7.0 nM and 2.2 nM, respectively. This small molecule is a valuable research tool for investigating oncogenic signaling and angiogenesis in both cellular and animal models of cancer.

Research Area

Cardiovascular Research, Cell Biology, Signal Transduction

Key Properties

• CAS Number: 1125632-93-0
• MW: 547.99
• Purity: 98.41% (May vary between batches)
• Formula: C₂₇H₁₉ClFN₅O₃S
• SMILES: Fc1ccc(Oc2ccc3nc(NC(=O)C4CC4)sc3n2)cc1NC(=O)c1cccc(c1Cl)C1(CC1)C#N
• Target: PERK,Raf,VEGFR
• Solubility: DMSO:65 mg/mL (118.62 mM)

Bioactivity

• Target IC50:
  Raf:7.0 nM|VEGFR2:2.2 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

antiangiogenesis, antitumor, inhibit, orally active, Inhibitor, HUVEC cells, PERK, Raf, Raf kinases, PKR-like endoplasmic reticulum kinase, Protein kinase R-like endoplasmic reticulum kinase, Takeda 6d, Takeda6d, Takeda-6D, Takeda-6d, VEGFR, VEGFR2, Vascular endothelial growth factor receptor

Compound Identifiers

PubChem CID

25206185