TAK-901

SKU: orb1700797

Description

TAK-901

Research Area

Cardiovascular Research, Cell Biology, Epigenetics & Chromatin, Signal Transduction, Stem Cell & Developmental Biology

Key Properties

• CAS Number: 934541-31-8
• MW: 504.64
• Purity: 99.39%
• Formula: C₂₈H₃₂N₄O₃S
• SMILES: CCS(=O)(=O)c1cccc(c1)-c1cc(C(=O)NC2CCN(C)CC2)c(C)c2[nH]c3ncc(C)cc3c12
• Target: Aurora Kinase,Src,JAK,CDK
• Solubility: DMSO:93 mg/mL (184.29 mM);Ethanol:< 1 mg/mL (insoluble or slightly soluble)

Bioactivity

• Target IC50:
  JAK3:1.2 nM|FGR < .0 nM|Aurora B:15 nM|c-Src:1.3 nM|YES1 < .0 nM|CLK2 < .0 nM|Aurora A:21 nM
• In Vivo:
  A large set of kinase assays showed that TAK-901 inhibited multiple kinases (including FLT3, FGFR and Src family kinases) with IC50 Values similar to those of Aurora A and B. TAK-901 inhibited Aurora A-TPX2 and Aurora B-INCENP in a tightly bound manner in a time-dependent manner.TAK-901 inhibited Aurora A-TPX2 and Aurora B-INCENP in a time-dependent manner. TAK-901 inhibite the NFkB and JAK/STAT pathways with submicromolar potency in a panel of pathway-specific Reporter gene-based cell models.TAK-901 inhibited cell proliferation in human tumor cell lines from various tissues with IC50 ranging from 40 to 500 nM.TAK-901 inhibite the proliferation of human PC3 prostate cancer and HL60 acute myeloid leukemia cells in human PC3 prostate cancer and HL60 acute myeloid leukemia cells as determined by immunofluorescence and flow cytometry. Myeloid leukemia cells, consistent with Aurora B inhibition.TAK-901 inhibited Flt3 and FGFR2 autophosphorylation in cells with IC50 Values close to those of Aurora B as measured by intracellular histidine H3 phosphorylation, wherea the IC50 for Inhibition of intracellular Src and Bcr Abl were 20-fold weaker.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Disclaimer: For research use only

Alternative Names

CLK2, c-Src, Aurora Kinase, AuroraKinase, Inhibitor, inhibit, JAK3, FGR, TAK 901, TAK901, TAK-901, Yes1

Compound Identifiers

PubChem CID

16124208