TAK-593

SKU: orb1307706

Description

TAK-593 is a potent small molecule inhibitor targeting VEGFR and PDGFR family kinases, with IC50 values in the low nanomolar range. It is a valuable research tool for studying angiogenesis and tumor microenvironment in both cellular assays and animal models of cancer and other proliferative diseases.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Signal Transduction

Key Properties

• CAS Number: 1005780-62-0
• MW: 445.47
• Purity: 99.37% (May vary between batches)
• Formula: C₂₃H₂₃N₇O₃
• SMILES: Cc1cc(C(=O)Nc2cc(Oc3ccc4nc(NC(=O)C5CC5)cn4n3)ccc2C)n(C)n1
• Target: VEGFR,PDGFR
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (4.49 mM);DMSO:45 mg/mL (101.02 mM)

Bioactivity

• Target IC50:
  VEGFR1:3.2 nM|VEGFR3:1.1 nM|VEGFR2:0.95 nM|PDGFRα:4.3 nM|PDGFRβ:13 nM|PDGFRα (V561D):1 nM
• In Vitro:
  TAK-593 inhibits the growth of HUVEC (IC50: 0.30 nM). TAK-593 also potently inhibits VEGF-induced tube formation of endothelial cells co-cultured with fibroblasts. TAK-593 potently inhibits VEGF- and PDGF-stimulated cellular phosphorylation and proliferation of human umbilical vein endothelial cells and human coronary artery smooth muscle cells. It displays effective inhibitory activity against VEGFR (VEGFR1-3: IC50=3.2, 0.95, 1.1 nM) and PDGFR (PDGFRα, β: IC50=4.3, 13 nM) families. Against other kinases, the IC50 values of TAK-593 are above 100 nM, except for Fms (IC50=10 nM) and Ret (IC50=18 nM) kinases .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PDGFRα (V561D), PDGFRαV561D, PDGFRα, PDGFRβ, PDGFR, Platelet-derived growth factor receptor, Inhibitor, inhibit, TAK 593, TAK593, TAK-593, Vascular endothelial growth factor receptor, VEGFR, VEGFR1, VEGFR2, VEGFR3

Compound Identifiers

PubChem CID

24767976