TAK-137

SKU: orb1738600

Description

TAK-137 is a positive allosteric modulator of AMPA receptors, investigated for its antidepressant and pro-cognitive effects. Its potential application in modeling cognitive deficits has established it as a tool compound for preclinical schizophrenia research in both in vitro and in vivo studies.

Research Area

Neuroscience, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1358749-55-9
• MW: 352.41
• Purity: 99.18%
• Formula: C₁₉H₁₆N₂O₃S
• SMILES: O=S1(=O)N=C2C(=CC=CN2CC1)C=3C=CC(OC=4C=CC=CC4)=CC3
• Target: iGluR

Bioactivity

• In Vivo:
  Oral administration of TAK-137 at 0.1-1 mg/kg to mice and 0.3-3 mg/kg to rats increased the proliferation of progenitor cells in the hippocampus. TAK-137 administered to monkeys at 0.03-1 mg/kg orally improved the cognitive performance of monkeys in the delayed matching sample task (DMTS).

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Orlistat d3, AMPAR, (–)-Tetrahydrolipstatin-d3, TAK 137, TAK137, TAK-137

Compound Identifiers

PubChem CID

56649286