tafamidis meglumine

SKU: orb1299686

Description

Tafamidis meglumine (Fx-1006A) is a selective transthyretin (TTR) kinetic stabilizer that potently inhibits amyloid fibril formation. This small molecule is widely used in research to investigate TTR amyloidosis mechanisms, supporting both in vitro binding assays and in vivo disease model studies.

Key Properties

• CAS Number: 951395-08-7
• MW: 503.33
• Purity: 99.98% (May vary between batches)
• Formula: C₂₁H₂₄Cl₂N₂O₈
• SMILES: CNC[C@H](O)[C@@H](O)[C@H](O)[C@H](O)CO.OC(=O)c1ccc2nc(oc2c1)-c1cc(Cl)cc(Cl)c1
• Target: Others
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (1.99 mM);DMSO:5.04 mg/mL (10.01 mM)

Bioactivity

• Target IC50:
  TTR:2.7-3.2 μM (EC50)
• In Vitro:
  Tafamidis selectively binds with negative cooperativity (K(d)s ~2 nM and ~200 nM) to the two thyroxine-binding sites of the TTR tetramer, kinetically stabilizing TTR. It also stabilizes patient-derived amyloidogenic TTR variants, including kinetically and thermodynamically less stable mutants.

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Fx-1006A, Inhibitor, Tafamidis, tafamidis meglumine

Compound Identifiers

PubChem CID

24970412