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Taccalonolide A
Catalog Number: orb1219391
| Catalog Number | orb1219391 |
|---|---|
| Category | Small Molecules |
| Description | Taccalonolide A is the first microtubule stabilizing agent to be discovered from a plant since identification of the mechanism of action of paclitaxel and it is the first natural product steroid identified to have these cellular effects,with cytotoxic and antimalarial activities. Taccalonolide A causes G2-M accumulation, Bcl-2 phosphorylation and initiation of apoptosis. |
| Target | microtubule |
| Purity | >98% (HPLC) |
| MW | 702.7 |
| CAS Number | 108885-68-3 |
| Formula | C36H46O14 |
| Storage | Storage temperature: -20°C. Stability: ≥ 2 years |
| Note | For research use only |
| Expiration Date | 12 months from date of receipt. |
Taccalonolide B [orb1219390]
>98% (HPLC)
108885-69-4
660.7
C34H44O13
200 mg, 100 mg, 25 mg, 10 mg, 1 g, 500 mg, 5 mgTaccalonolide A [orb1297196]
99.40%
108885-68-3
702.74
C36H46O14
5 mg, 1 ml x 10 mM (in DMSO), 10 mg, 1 mg
For example, if the dosage of your experiment is 10mg/kg, the weight of each animal is 50g, and the volume of the dosing is 100μL, then the working solution concentration of your experiment is 5mg/mL. If the formula you used is 5% DMSO+ 30% PEG300+ 5% Tween 80 + 60% Saline/PBS/ddH2O, the preparation method is as follows:
Mother liquor preparation method: 5mg of drug dissolved in 100μL DMSO (mother liquor concentration is 50mg/mL). Preparation method of in vivo formulation: For 1mL of working solution preparation, take 50μL of DMSO mother liquor, add 300 μL of PEG300 to mix well and clarify, then add 50μL of Tween-80 to mix well and clarify, and finally add 600μL of Saline/PBS/ddH2O to mix well and clarify.Note:
- For Reference Only. Please choose the appropriate dissolution protocol according to your experimental animal and administration method.
- We suggest that in cell experiments, the final concentration of DMSO is not more than 0.1%, in animal experiments, for healthy mice, the final concentration of DMSO is not more than 10%; For nude or frail mice, the final concentration of DMSO is not more than 2%.
