Taccalonolide A

SKU: orb1219391

Description

Taccalonolide A is the first microtubule stabilizing agent to be discovered from a plant since identification of the mechanism of action of paclitaxel and it is the first natural product steroid identified to have these cellular effects,with cytotoxic and antimalarial activities. Taccalonolide A causes G2-M accumulation, Bcl-2 phosphorylation and initiation of apoptosis. Taccalonolide A is effective in vitro against cell lines that overexpress P-glycoprotein (Pgp) and multidrug resistance protein 7 (MRP7), with an IC50 of 622 nM for SK-OV-3 cells.

Key Properties

• CAS Number: 108885-68-3
• MW: 702.74
• Purity: >98% (HPLC)
• Formula: C₃₆H₄₆O₁₄
• SMILES: C[C@@]12[C@]([C@@H](OC(C)=O)[C@]3([H])[C@]2([H])[C@@H](C=C(O4)[C@@]3([C@](O)(C4=O)C)C)C)([H])[C@@]([C@H]5O)([H])[C@]([C@]6([C@H]([C@@H](O7)[C@@H]7C[C@]6([H])C5=O)OC(C)=O)C)([H])[C@H](OC(C)=O)[C@@H]1OC(C)=O
• Target: Microtubule/Tubulin
• Solubility: In Vitro: DMSO : 100 mg/mL (142.30 mM)

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Microtubule/Tubulin