T3Inh-1

SKU: orb1297920

Description

T3Inh-1 is a selective ppGalNAc-T3 inhibitor (IC50 = 7 µM) with demonstrated activity in breast cancer cell protection and in vivo reduction of FGF23 hormone levels in mice, showing no observed toxicity. Its applications span cancer research and studies of hormone regulation in both cellular and animal models.

Key Properties

• CAS Number: 50440-30-7
• MW: 476.49
• Purity: 97.32% (May vary between batches)
• Formula: C₂₇H₂₀N₆O₃
• SMILES: O=C(NC1=CC=C(C=C1)NC2=CC=NC=C2)C(C=C3)=CC=C3NC4=CC=NC5=C4C=C([N+]([O-])=O)C=C5
• Target: Others
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.1 mM);DMSO:4.77 mg/mL (10.01 mM)

Bioactivity

• Target IC50:
  ppGalNAc-T3:7 µM
• In Vivo:
  METHODS: Mice were injected intraperitoneally with T3Inh-1 and serum cleaved FGF23 levels were measured. Three groups of T3Inh-1 (25 and 50 mg/kg, intraperitoneal injection, 24 hours) were administered and serum cleaved FGF23 levels were measured. RESULTS T3Inh-1 resulted in a robust and statistically significant increase in this ratio at the tested concentrations of 25 and 50 mg/kg, suggesting that T3Inh-1 can mitigate the effects of elevated FGF23 signaling in patients with chronic kidney disease.
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• In Vitro:
  METHODS: Breast cancer MDA-MB231 cells were treated with T3Inh-1 (5μM, 24/48 hours) to observe cell proliferation and cell invasion. RESULTS T3Inh-1 was significantly effective, inhibiting migration by >80% and invasion by 98%, but had no significant effect on cell proliferation.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

T3Inh 1, T3Inh1, T-3Inh-1, T3Inh-1, ppGalNAc-T3, Inhibitor, FGF23, inhibit, invasion, O-glycosylation, breast cancer cells

Compound Identifiers

PubChem CID

4532204