T16Ainh-A01

SKU: orb1309042

Description

T16Ainh-A01 is a potent and selective small-molecule inhibitor of the TMEM16A calcium-activated chloride channel (CaCC), exhibiting an IC50 of approximately 1 μM. This tool compound is widely used in vitro to investigate the physiological roles of TMEM16A in secretory epithelia, smooth muscle contraction, and cancer cell proliferation.

Research Area

Pharmacology & Drug Discovery

Key Properties

• CAS Number: 552309-42-9
• MW: 416.52
• Purity: 98.15% (May vary between batches)
• Formula: C₁₉H₂₀N₄O₃S₂
• SMILES: CCc1c(C)[nH]c(SCC(=O)Nc2nc(cs2)-c2ccc(OC)cc2)nc1=O
• Target: Chloride channel
• Solubility: H2O:Insoluble;DMF:10 mg/mL (24.01 mM);DMSO:4.18 mg/mL (10.04 mM)

Bioactivity

• Target IC50:
  TMEM16A (Cl- channel):1 µM
• In Vitro:
  T16Ainh-A01 (0.3-30μM) can significantly reduce the inward and outward components of IClCa and inhibit IClCa in RUICC without significantly affecting L-type Ca2+ current. T16Ainh-A01 (10 μM) inhibits nearly completely TMEM16A chloride current (induced by 275 nM free calcium in the pipette) at all voltages, indicating a voltage-independent block mechanism.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

T16Ainh A01, T16AinhA01, T-16Ainh-A01, T16Ainh-A01, TMEM16A, TMEM16A Chloride channel, Cl-Channels, Chloridechannel, Chloride channel, Chloride Channel, inhibit, Inhibitor

Compound Identifiers

PubChem CID

135460621