T133

SKU: orb3210137

Description

T133 is an orally active ATP-competitive mTOR inhibitor with an IC50 of 0.34 nM and a Ki of 0.17 nM. It effectively inhibits the phosphorylation of AKT, S6K1, and 4EBP1. T133 suppresses the proliferation and migration of cancer cells, inducing apoptosis, cell cycle arrest, and autophagy. It demonstrates dose-dependent antitumor efficacy in xenograft mouse models. T133 is applicable in cancer research, including gastric and lung cancers.

Key Properties

• CAS Number: 3101627-06-6
• MW: 421.41
• Formula: C₂₁H₁₉N₅O₅
• SMILES: O=C1N(C=2C(N=C1C=3C=4C(OC3)=CC(O)=CC4)=C(N)N=CN2)[C@@H]5CC[C@@H](C(O)=O)CC5
• Target: Apoptosis,Autophagy,Akt,mTOR,S6 Kinase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

Apoptosis,Autophagy,Akt,mTOR,S6 Kinase