T1001

SKU: orb1740400

Description

T1001 is a small molecule antagonist targeting HIF-2α. It functions by binding to the PAS-B domain, displacing residue M252 and disrupting the HIF-2α/ARNT heterodimerization. This inhibitor is a valuable tool for studying hypoxia signaling pathways in cancer and renal physiology through in vitro and in vivo models.

Key Properties

• CAS Number: 56943-06-7
• MW: 283.19
• Formula: C₁₁H₁₁BrN₂S
• SMILES: BrC1=CC=C([C@H]2CN3C(=N2)SCC3)C=C1
• Target: Others

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Compound Identifiers

PubChem CID

688042