T-1101 tosylate

SKU: orb1299115

Description

T-1101 tosylate (TAI-95 tosylate) is a small molecule inhibitor targeting the Hec1/Nek2 interaction, exhibiting antitumor properties. It has demonstrated activity in both in vitro cellular assays and in vivo xenograft models, supporting its investigation in cancer research, particularly for mitosis-targeted therapies.

Research Area

Cell Biology, Signal Transduction

Key Properties

• CAS Number: 2250404-95-4
• MW: 665.8
• Purity: 98.47% (May vary between batches)
• Formula: C₃₁H₃₁N₅O₆S₃
• SMILES: Cc1ccc(cc1)S(O)(=O)=O.COCCOc1cnc(Sc2cc(C)c(-c3csc(NC(=O)c4ccncc4)n3)c(C)c2)cn1
• Target: Apoptosis,MAPK,Microtubule Associated
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (3 mM);DMSO:11 mg/mL (16.52 mM)

Bioactivity

• In Vivo:
  T-1101 tosylate can achieve high concentrations in Huh-7 and MDA-MB-231 tumor tissues, and showed promise in antitumor activity in mice bearing human tumor xenografts of liver cancer (Huh-7).
• In Vitro:
  T-1101 has good oral absorption, along with potent in vitro antiproliferative activity (IC50: 14.8-21.5 nM).
• Animal Research:
  SCID mice bearing human Huh-7, BT-474, MCF-7, and MDA-MB-231 xenografts. Dosage:25 mg/kg, 50 mg/kg. Oral administration; twice per day; 28 days

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Inhibitor, Hec1, Hec1/Nek2, MicrotubuleAssociated, Microtubule Associated, inhibit, Apoptosis, PPI, TAI 95, TAI 95 Tosylate, TAI95, TAI-95, TAI95 Tosylate, TAI-95 tosylate, TAI-95 Tosylate, T1101, T-1101, T1101 Tosylate, T1101 tosylate, T-1101 Tosylate, T 1101, T 1101 Tosylate, T 1101 tosylate

Compound Identifiers

PubChem CID

71586372