T-00127_HEV1

SKU: orb1307709

Description

T-00127_HEV1 is a potent and selective small molecule inhibitor of phosphatidylinositol 4-kinase III beta (PI4KIIIβ) with an IC50 of 60 nM. This compound is a valuable research tool for studying PI4KIIIβ's role in lipid signaling, viral replication, and cellular trafficking in both in vitro and in vivo experimental systems.

Research Area

Signal Transduction

Key Properties

• CAS Number: 900874-91-1
• MW: 411.5
• Purity: 99.89% (May vary between batches)
• Formula: C₂₂H₂₉N₅O₃
• SMILES: COc1ccc(cc1OC)-c1c(C)nn2c(NCCN3CCOCC3)cc(C)nc12
• Target: PI4K
• Solubility: DMSO:6 mg/mL (14.58 mM);10% DMSO+40% PEG300+5% Tween 80+45% Saline:1 mg/mL (2.43 mM)

Bioactivity

• Target IC50:
  Antipoliovirus (PV):0.77 μM(EC50)|PI4KIIIβ:60 nM
• In Vitro:
  T-00127_HEV1 displays a more potent anti-poliovirus activity (EC50: 0.77 μM) than other candidate compounds (EC50: 1.7 to 4.7 μM). GW5074 and T-00127_HEV1 almost fully inhibit PI4KB kinase activity at 10 μM (3% and 5% of residual activity, respectively), in contrast to AN-12-H5 (108% of activity [no inhibition]) .
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

inhibit, Inhibitor, T 00127_HEV1, T00127_HEV1, T-00127_HEV1, T-00127_HEV-1, PI4KIIIβ, PI4 kinases, PI4K, PI4KB, Phosphatidylinositol 4 kinases

Compound Identifiers

PubChem CID

4904109