SYR127063

SKU: orb1304165

Description

SYR127063 (BDBM-92454) is a potent and selective inhibitor targeting the HER2 receptor by binding to its reactive conformation. This compound is a valuable research tool for investigating HER2-driven cancers in both cellular and animal models, facilitating studies in oncology and targeted therapy development.

Research Area

Cardiovascular Research, Signal Transduction

Key Properties

• CAS Number: 871026-18-5
• MW: 492.88
• Purity: 98.57%
• Formula: C₂₃H₂₀ClF₃N₄O₃
• SMILES: OCCOCCn1ccc2ncnc(Nc3ccc(Oc4cccc(c4)C(F)(F)F)c(Cl)c3)c12
• Target: EGFR,HER
• Solubility: H2O:Insoluble;DMSO:55 mg/mL (111.59 mM)

Bioactivity

• Target IC50:
  EGFR:429 nM|HER4: > 10000 nM|HER2:11 nM
• In Vitro:
  IC50 data: HER2 = 11 nM; EGFR = 429 nM; HER4 > 10000 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

EGFR, HER2, HER4, BDBM 92454, BDBM92454, BDBM-92454, SYR 127063, SYR127063, SYR-127063

Compound Identifiers

PubChem CID

11684629