SYP-5

SKU: orb1309044

Description

SYP-5 is a small molecule HIF-1α inhibitor that impedes tumor cell invasion and angiogenesis. It is a valuable research tool for studying hypoxia signaling in oncology, with applications in both in vitro cell-based assays and in vivo xenograft models for cancer metastasis and angiogenesis research.

Research Area

Cardiovascular Research, Epigenetics & Chromatin, Metabolism Research, Signal Transduction

Key Properties

• CAS Number: 1384268-04-5
• MW: 312.38
• Purity: 99.10% (May vary between batches)
• Formula: C₁₈H₁₆O₃S
• SMILES: CC1(C)Oc2ccc(C(=O)\C=C\c3cccs3)c(O)c2C=C1
• Target: HIF,HIF/HIF Prolyl-Hydroxylase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:2 mg/mL (6.4 mM);DMSO:33.33 mg/mL (106.7 mM)

Bioactivity

• In Vitro:
  A novel HIF-1 inhibitor SYP-5 was first observed by the luciferase reporter assay. Western blots results showed SYP-5 inhibited hypoxia-induced upregulation of HIF-1. Moreover, the proteins of vascular endothelial growth factor (VEGF) and matrix metalloproteinases (MMP)-2 that are targets of HIF-1, were down-regulated by SYP-5. Furthermore, in the tube formation assay, SYP-5 suppressed angiogenesis induced by hypoxia and VEGF in vitro. Additionally, using Transwell and RTCA assays, we found that SYP-5 also retarded the Hep3B and Bcap37 cells migration and invasion induced by hypoxia and FBS. Detected the upstream pathways related to HIF-1 and found both PI3K/AKT and MAPK/ERK were involved in the SYP-5 mediated invasive inhibition of Bcap37 cells. SYP-5 inhibits tumor cell migration and invasion, as well as tumor angiogenesis, which are mediated by suppressing PI3K/AKT- and MAPK/ERK-dependent HIF-1 pathway. It suggests that SYP-5 might be a potential HIF-1 inhibitor as an anticancer agent.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Hypoxia-inducible factors, HIFs, HIFProlylHydroxylase, HIF-PH, HIF, HIF/HIFProlylHydroxylase, HIF/HIF Prolyl-Hydroxylase, HIF ProlylHydroxylase, HIF Prolyl-Hydroxylase, HIF/HIF ProlylHydroxylase, inhibit, Inhibitor, SYP 5, SYP5, SYP-5

Compound Identifiers

PubChem CID

123131800