Synta66

SKU: orb1309047

Description

Synta66 is a selective inhibitor of the Orai store-operated calcium entry channel. It is a valuable research tool for investigating calcium signaling in neurological diseases, with applications in both in vitro and in vivo experimental models.

Research Area

Metabolism Research, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 835904-51-3
• MW: 352.36
• Purity: 99.84% (May vary between batches)
• Formula: C₂₀H₁₇FN₂O₃
• SMILES: COc1ccc(OC)c(c1)-c1ccc(NC(=O)c2ccncc2F)cc1
• Target: Calcium Channel
• Solubility: 10% DMSO+90% Corn Oil:2.5 mg/mL (7.1 mM);DMSO:50 mg/mL (141.9 mM)

Bioactivity

• In Vitro:
  Synta66 is an Orai inhibitor, which forms the pore of the CRAC channel. Synta66 (10 μM) suppresses human platelet activation in plasma, whole-blood thrombus formation, and inhibits the LAD2 human mast cell line.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

Calcium release-activated channels, CalciumChannel, Calcium Channel, Ca2+ release-activated Ca2+ channels, CRAC Channel, inhibit, Orai, Inhibitor, Synta 66, Synta66, Synta-66

Compound Identifiers

PubChem CID

11337104