SYN1143

SKU: orb1685385

Description

SYN1143 (AMG-1) is a highly potent small molecule inhibitor targeting the RON and c-Met receptor tyrosine kinases, exhibiting in vitro IC50 values of 9 nM and 4 nM, respectively. This compound is a valuable research tool for investigating cancer cell signaling, proliferation, and metastasis in both cellular and animal models of various malignancies.

Research Area

Signal Transduction

Key Properties

• CAS Number: 913376-84-8
• MW: 556.58
• Purity: 99.69% (May vary between batches)
• Formula: C₃₁H₂₉FN₄O₅
• SMILES: COc1ccc2c(Oc3ccc(NC(=O)c4c(C)n(CC(C)(C)O)n(-c5ccccc5)c4=O)cc3F)ccnc2c1
• Target: c-Met/HGFR
• Solubility: DMSO:90 mg/mL (161.7 mM)

Bioactivity

• Target IC50:
  RON:9 nM|c-Met:4 nM

Storage & Handling

• Storage: Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SYN 1143, SYN1143, SYN-1143, RON-IN-1, RON, tumor, inhibit, Inhibitor, HGFR, cancer, AMG 1, AMG1, AMG-1, c-Met/HGFR, cMet, c-Met, cMet/HGFR, dual

Compound Identifiers

PubChem CID

16757524