SY-5102

SKU: orb3174133

Description

SY-5102 is a potent, selective, orally active cyclin-dependent kinase (CDK7) inhibitor with a Kd of 0.03 nM. It exhibits antiproliferative activity against HCC70 cells with an EC50 of 9 nM. SY-5102 inhibits CDK7-mediated CAK function [downregulating CDK2Thr160 phosphorylation] and TFIIH transcription function [downregulating RNA polymerase II Ser5 phosphorylation]. The compound induces G2/M cell cycle arrest, downregulates the expression of the oncogene c-Myc, and ultimately triggers apoptosis in cancer cells. SY-5102 is applicable for research in triple-negative breast cancer (TNBC).

Research Area

Cell Biology, Metabolism Research

Key Properties

• CAS Number: 2365230-48-2
• MW: 457.46
• Formula: C₂₂H₂₂F₃N₇O
• SMILES: C(F)(F)(F)C=1C(C=2C=3C(NC2)=NC(=CC3)C=4C(C)=NOC4C)=NC(N[C@H]5CCCNC5)=NC1
• Target: CDK,Apoptosis,c-Myc,Serine/threonin kinase

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Quick Database Links

Gene Symbol

CDK,Apoptosis,c-Myc,Serine/threonin kinase