SX-517

SKU: orb1699203

Description

SX-517 is a potent non-competitive dual antagonist of CXCR1/2 receptors. It exhibits anti-inflammatory activity by inhibiting CXCL-1-induced calcium mobilization and CXCL-8-mediated GTPγS binding, while also suppressing ERK1/2 phosphorylation in cellular assays and mouse models.

Research Area

Cell Biology, Immunology & Inflammation, Pharmacology & Drug Discovery

Key Properties

• CAS Number: 1240494-13-6
• MW: 382.22
• Purity: 99.90% (May vary between batches)
• Formula: C₁₉H₁₆BFN₂O₃S
• SMILES: O=C(NC1=CC=C(F)C=C1)C2=CN=C(SCC=3C=CC=CC3B(O)O)C=C2
• Target: CXCR
• Solubility: DMSO:80 mg/mL (209.3 mM);10% DMSO+40% PEG300+5% Tween-80+45% Saline:3.3 mg/mL (8.63 mM)

Bioactivity

• In Vivo:
  SX-517 (0.02 mg/kg and 0.2 mg/kg) was administered via single intravenous injection to male CD1 SWISS mice bearing utetheisa ornatrix air pouches on their backs. The results demonstrated a significant reduction in cell counts within the utetheisa ornatrix air pouches of the mice .
• In Vitro:
  SX-517 (0.1 nM-0.1 mM; 60 minutes) inhibited 10 nM CXCL8-induced [35S]GTPγS binding with an IC50 of 60 nM . SX-517 (10 μM; 60 minutes) suppressed the cell surface expression of CXCR2 receptors in HEK293 cells . SX-517 (10 μM; 0-30 minutes) blocked CXCR2-mediated ERK1/2 phosphorylation in HEK293 cells .

Storage & Handling

• Storage: keep away from moisture,keep away from direct sunlight | Powder: -20°C for 3 years | In solvent: -80°C for 1 year | Shipping with blue ice/Shipping at ambient temperature.
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

SX 517, SX517, SX-517

Compound Identifiers

PubChem CID

46897162