SW2_110A

SKU: orb1693435

Description

SW2_110A is a cell-permeable, selective inhibitor of the chromodomain of CBX8 with a Kd of 800 nM, demonstrating 5-fold selectivity over other CBX family members. This small molecule is a valuable chemical probe for investigating Polycomb repressive complex 1 (PRC1) function in epigenetic regulation, cancer biology, and stem cell research in both cellular and biochemical assays.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 2579696-95-8
• MW: 760.96
• Purity: 98.00% (May vary between batches)
• Formula: C₄₂H₆₀N₆O₇
• SMILES: [C@H](C(N[C@H](C(N[C@H](C(N[C@H](C(NCC#C)=O)CO)=O)CCCCN(CC)CC)=O)[C@@H](CC)C)=O)(NC(=O)C1=CC=C(OC2=CC=CC=C2)C=C1)[C@H]3CCCC3
• Target: Histone Methyltransferase
• Solubility: 10% DMSO+40% PEG300+5% Tween 80+45% Saline:4 mg/mL (5.26 mM);DMSO:112.5 mg/mL (147.84 mM)

Bioactivity

• Target IC50:
  CBX8 ChD:800 nM(Kd )
• In Vitro:
  SW2_110A (100 µM; 24h) explicitly inhibits the association of CBX8 with chromatin in cells and inhibits the proliferation of THP1 leukemia cells driven by the MLL-AF9 translocation (IC50 of 26 µM). In THP1 cells, SW2_110A (100 µM; 24h) treatment results in a significant decrease in the expression of MLL-AF9 target genes, including HOXA9.
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Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

CBX8, HistoneMethyltransferase, Histone Methyltransferase, SW2_110A, SW-2_110A

Compound Identifiers

PubChem CID

171360491