SW155246

SKU: orb1685336

Description

SW155246 is a potent and selective DNMT1 inhibitor (IC50 = 1.2 µM) that reactivates silenced tumor suppressor genes, such as RASSF1, in cellular models like A549 lung carcinoma cells. This compound is a valuable chemical probe for epigenetic research, enabling the study of DNA methylation's role in cancer biology and gene expression both in vitro and in vivo.

Research Area

Epigenetics & Chromatin

Key Properties

• CAS Number: 420092-79-1
• MW: 378.79
• Purity: 98.99% (May vary between batches)
• Formula: C₁₆H₁₁ClN₂O₅S
• SMILES: Oc1ccc(NS(=O)(=O)c2ccc(Cl)c(c2)[N+]([O-])=O)c2ccccc12
• Target: DNA Methyltransferase
• Solubility: DMSO:50 mg/mL (132 mM)

Bioactivity

• Target IC50:
  DNMT1:1.2 μM

Storage & Handling

• Storage: -20°C
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

DNAMethyltransferase, DNMT1, DNMT1 inhibitor, DNMTs, DNA Methyltransferase, DNA MTases, cancer, mDNMT3A, Inhibitor, hDNMT1, inhibit, SW155246, SW-155246, SW 155246

Compound Identifiers

PubChem CID

3718032