Sutezolid

SKU: orb1225967

Description

An oxazolidinone antibiotic that possesses potent antituberculosis activity in vitro and in vivo; significantly shorten the duration of therapy for drug-susceptible as well as multidrug-resistant tuberculosis.Bacterial Infection Phase 2 Clinical(In Vitro):Sutezolid (PNU-100480) exhibits excellent in vitro activity against multiple clinical isolates of Mycobacterium avium complex (MIC’s=0.5-4 μg/mL).(In Vivo):Sutezolid (PNU-100480) is a thiomorpholinyl analog of linezolid with superior efficacy against M. tuberculosis in the hollow-fiber, mouse, and whole-blood models.

Key Properties

• CAS Number: 168828-58-8
• MW: 353.4117
• Purity: >98% (HPLC)
• Formula: C₁₆H₂₀FN₃O₃S
• SMILES: CC(NC[C@H]1CN(C2=CC=C(N3CCSCC3)C(F)=C2)C(O1)=O)=O
• Target: Antibacterial
• Solubility: 10 mM in DMSO

Bioactivity

• In Vivo:
  Sutezolid (PNU-100480) is a thiomorpholinyl analog of linezolid with superior efficacy against M. tuberculosis in the hollow-fiber, mouse, and whole-blood models.
• In Vitro:
  Sutezolid (PNU-100480) exhibits excellent in vitro activity against multiple clinical isolates of Mycobacterium avium complex (MIC’s=0.5-4 μg/mL).

Storage & Handling

• Storage: Storage temperature: -20°C. Stability: ≥ 2 years
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

PNU-100480 | PNU100480 | PF-02341272 | PF02341272 | U-100480

Quick Database Links

Gene Symbol

Antibacterial