Surfactin

SKU: orb1309048

Description

Surfactin is a cyclic lipopeptide biosurfactant that facilitates the transmembrane transport of cations like calcium. It is widely used in research for its membrane-disrupting properties, applied in studies of antimicrobial mechanisms, hemolysis, and membrane biophysics in both in vitro and in vivo experimental models.

Research Area

Infectious Disease & Virology, Signal Transduction

Key Properties

• CAS Number: 24730-31-2
• MW: 1036.34
• Purity: mixture
• Formula: C₅₃H₉₃N₇O₁₃
• SMILES: CC(C)CCCCCCCCCCCC(=O)N1[C@@H](C(O)CC(O)=O)C(=O)N[C@@H](CC(C)C)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(O)=O)C(=O)N[C@H](CC(C)C)C(=O)N[C@@H](CC(C)C)C1=O
• Target: Integrin,HSV
• Solubility: 10% DMSO+40% PEG300+5% Tween-80+45% Saline:2 mg/mL (1.93 mM);DMSO:257.5 mg/mL (248.47 mM);H2O:28.25 mg/mL (27.26 mM)

Bioactivity

• In Vivo:
  in the model of chick infection, surfactin exerted adjuvant effects with amoxicillin against APEC by lowering the numerical value of mortality and liver bacterial loads, and regulating the expression of inflammatory cytokines et al.We concluded that surfactin can act as a novel antimicrobial adjuvant with amoxicillin against AEPC infection in chicken.
• In Vitro:
  Surfactin is used as a surfactant to mediate flux of mono-and divalent cations, such as calcium, across lipid bilayer membranes. surfactin can increase the activity of amoxicillin against avian pathogenic Escherichia coli (APEC) in vitro with antimicrobial assays such as minimum inhibitory concentrations (MIC) and fractional inhibitory concentration (FIC).

Storage & Handling

• Storage: keep away from moisture | Powder: -20°C for 3 years | In solvent: -80°C for 1 year
• Expiration Date: 12 months from date of receipt.
• Disclaimer: For research use only

Alternative Names

HSV-1, Surfactin

Compound Identifiers

PubChem CID

137699381